Glucose-level dependent brain hypometabolism in type 2 diabetes mellitus and obesity

Abstract Background Metabolic syndrome and its individual components lead to wide-ranging consequences, many of which affect the central nervous system. In this study, we compared [ 18 F]FDG regional brain metabolic pattern participants with type 2 diabetes mellitus (T2DM) non-DM obese individuals. Methods our prospective 51 patients controlled T2DM (ages 50.6 ± 8.0 years) 45 52.0 9.6 were enrolled. Glucose levels measured before PET/CT examination (pre-PET glucose) as well laboratory parameters assessing glucose lipid status determined. NeuroQ application (NeuroQ TM 3.6, Syntermed, Philips) was used evaluate differences. (AnyScan PC, Mediso) scans, estimating metabolism, transformed MNI152 map after T1 registration for SPM-based group comparison metabolism corrected pre-PET glucose, correlation analysis parameters. Results did not reveal significant defects in either group. Voxel-based revealed significantly ( P FWE <0.05) decreased region precuneus right superior frontal gyrus (rSFG) diabetic patients. Data level showed a hypometabolic difference only rSFG T2DM. negative following regions diabetes: precuneus, left posterior orbital gyrus, calcarine cortex part inferior gyrus; whilst rolandic (pericentral) operculum proved be sensitive level. Conclusions To knowledge, is first study perform comparative obesity. We also examined dependency cerebral two groups separately. Large-scale future studies are warranted further aim determining effects disturbances on metabolism.